The church of Saint Rocco is, most likely, identified with the building built in honor of Saint Rocco following a plague epidemic that broke out in Nepi in 1467. The structure has a simple facade, with no decorations also due to subsequent renovations.

It is structured with a single hall, probably greater in origin, and with a side chapel where, inside a lunette, it is possible to see a fresco representing the saint that could be dated at the end of the 15th century.

The painting consists of a central square, occupied by the figure of Saint Rocco, and four side panels that illustrate important moments in his life.

The saint is depicted in a pilgrim’s suit, with a hat, saddlebag and stick, and his left hand indicating the wound on his uncovered thigh. The commissioner of the fresco, a notable representative of the Nepi community, knelt in front of him.

The last box below depicts the death of Saint Rocco who died of hardship in prison after being arrested on charges of espionage, not wanting to reveal his identity. Two angels accompany his soul to heaven. A writing recalls that anyone who commends himself to him with sincere devotion will be freed from the plague.

As protector of pestilences his cult spread throughout Western Europe starting in the second half of the 14th century.